| Date & Time | Favorite | Line | Underdog | Total |
| 12/6 8:25 ET | Denver | -10 | At Oakland | 47 |
| 12/9 1:00 ET | At Washington | -2.5 | Baltimore | 47.5 |
| 12/9 1:00 ET | At Cleveland | -6.5 | Kansas City | 38 |
| 12/9 1:00 ET | At Pittsburgh | -7.5 | San Diego | 42.5 |
| 12/9 1:00 ET | At Indianapolis | -5.5 | Tennessee | 48 |
| 12/9 1:00 ET | NY Jets | -2.5 | At Jacksonville | 38.5 |
| 12/9 1:00 ET | Chicago | -3 | At Minnesota | 39 |
| 12/9 1:00 ET | Atlanta | -3.5 | At Carolina | 48 |
| 12/9 1:00 ET | At Tampa Bay | -7.5 | Philadelphia | 47.5 |
| 12/9 1:00 ET | At Buffalo | -3 | St. Louis | 42.5 |
| 12/9 1:00 ET | At Cincinnati | -3 | Dallas | 45.5 |
| 12/9 4:05 ET | At San Francisco | -10 | Miami | 39 |
| 12/9 4:25 ET | At NY Giants | -5 | New Orleans | 53 |
| 12/9 4:25 ET | At Seattle | -10 | Arizona | 35.5 |
| 12/9 8:30 ET | At Green Bay | -7 | Detroit | 50.5 |
| 12/10 8:40 ET | At New England | -3.5 | Houston | 51 |
